Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2) TFA is a potent peptide antagonist of FZD7 receptors , selectively binds to FZD7 CRD subclass and alters the conformation of the CRD and the architecture of its lipid-binding groove. The EC50 values are 58 and 34 nM for human and mouse FZD7 CRD, respectively. Fz7-21 TFA impairs the function of FZD7 in Wnt-beta-catenin signalling and stem cell function in intestinal organoids[1][2].
Molecular Weight:
1910.07
Purity:
99.35
Formula:
C85H115N18F3O25S2
Target:
Wnt
Application Notes:
Peptides
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