GpTx-1 TFA is a peptide-based NaV1.7 sodium channel antagonist isolated from the venom of the Chilean spider Grammostola porter. GpTx-1 TFA demonstrates potent inhibitory activity against the NaV1.7 channel with an IC50 value of 10 nM, while exhibiting excellent selectivity for NaV1.4 (IC50 = 0.301 µM) and NaV1.5 (IC50 = 4.20 µM), showing >20-fold and >950-fold selectivity respectively[1].
Molecular Weight:
4073.82 (free base)
Purity:
99.56
Formula:
C176H271N53O45S7.xC2HF3O2
Target:
Sodium Channel
Application Notes:
Peptides
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