TRV120027, a beta-arrestin-1-biased agonist of the angiotensin II receptor type 1 (AT1R), engages beta-arrestins while blocking G-protein signaling[1]. TRV120027 induces acute catecholamine secretion through cation channel subfamily C3 (TRPC3) coupling, promotes the formation of a macromolecular complex composed of AT1R-beta-arrestin-1-TRPC3-PLCgamma at the plasma membrane. TRV120027 inhibits angiotensin II-mediated vasoconstriction and increases cardiomyocyte contractility. TRV120027 has the potential for the acute decompensated heart failure (ADHF) treatment[2].
Molecular Weight:
926.07
Purity:
98.2
CAS Number:
[1234510-46-3]
Formula:
C43H67N13O10
Target:
Angiotensin Receptor,Arrestin
Application Notes:
MCE Product type: Peptides
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