ELA-32(human) TFA is a potent, high affinity apelin receptor agonist (IC50=0.27 nM, Kd=0.51 nM). ELA-32(human) TFA exhibits no binding GPR15 and GPR25. ELA-32(human) TFA activates the PI3K/AKT pathway and promotes self-renewal of hESCs via cell-cycle progression and protein translation. ELA-32(human) TFA also potentiates the TGFbeta pathway, priming hESCs toward the endoderm lineage. ELA-32(human) TFA stimulates angiogenesis in HUVEC cells.
Molecular Weight:
3967.82 (free acid)
Purity:
99.93
Formula:
C170H289N63O39S4.xC2HF3O2
Target:
Apelin Receptor (APJ)
Application Notes:
MCE Product type: Peptides
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