Bone morphogenetic protein 2 (BMP-2) is a pleiotropic ligand protein belonging to TNFbeta family, and is involved in key embryonic development of vascular and valvular homeostasis. BMP-2 binds to type I receptors (ALK-2/-3/-6) and type II receptors (BMPR2, ACVR2A) to regulate various types of calcification, including atherosclerosis, chronic kidney disease, diabetes, and valve calcification[1]. BMP-2 is overexpressed by myofibroblast and preosteoblast in the calcified area of human calcified valve, which are densely infiltrated by B lymphocytes and T lymphocytes[2]. BMP-2 is the junction between atherosclerotic vascular calcification and normal bone formation mechanism[3]. BMP-2 Protein, Human/Mouse/Rat is 114 a.a. (Q283-R396), expressed in E. coli.
Molecular Weight:
Approximately 13 kDa, based on SDS-PAGE under reducing conditions.
Purity:
98.00
Formula:
650(Gene_ID)P12643 (Q283-R396)(Accession)
Application Notes:
MCE Product type: Recombinant Proteins
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