Nicastrin is an important subunit of the gamma-secretase complex and plays a key role in the endoproteolytic cleavage of integral membrane proteins, including Notch receptors and amyloid-beta precursor protein (APP). In the gamma-secretase complex, nicastin acts as a key regulator of Notch and Wnt signaling cascades and affects downstream processes. Nicastrin Protein, Mouse (HEK293, hFc) is the recombinant mouse-derived Nicastrin protein, expressed by HEK293 , with C-hFc labeled tag.
Molecular Weight:
Approximately 117 kDa,based on SDS-PAGE under reducing conditions,due to the glycosylation.
Formula:
59287(Gene_ID)P57716 (G28-E668)(Accession)
Application Notes:
MCE Product type: Recombinant Proteins
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