Citronellol (()-Citronellol) is an orally active inducer of apoptosis. Citronellol can prevent oxidative stress, mitochondrial dysfunction, and apoptosis in the SH-SY5Y cell Parkinsons disease model induced by 6-OHDA by regulating the ROS-NO, MAPK/ERK, and PI3K/Akt signaling pathways. Citronellol can induce necroptosis in human lung cancer cells through the TNF-alpha pathway and accumulation of ROS. Citronellol can reduce the levels of LC-3 and p62 to regulate the autophagy pathway, inhibit oxidative stress and neuroinflammation, and thus have neuroprotective effects on Parkinsons rats. Citronellol exhibits anti-fungal activity against Trichophyton rubrum by inhibiting ergosterol synthesis[2][4][6][7].
Molecular Weight:
156.27
Purity:
98.78
CAS Number:
[106-22-9]
Formula:
C10H20O
Target:
Apoptosis,Atg8/LC3,Autophagy,ERK,Fungal,Necroptosis,p62,PI3K,Reactive Oxygen Species (ROS),TNF Receptor
Application Notes:
MCE Product type: Natural Products
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