4-Methyl-2-oxopentanoic acid (alpha-Ketoisocaproic acid) is a metabolite of L-leucine and is involved in energy metabolism. 4-Methyl-2-oxopentanoic acid increases endoplasmic reticulum stress, promotes lipid accumulation in preadipocytes and insulin resistance by impairing mTOR and autophagy signaling pathways. 4-Methyl-2-oxopentanoic acid also causes oxidative damage, leading to cognitive deficits, inhibits alpha-ketoglutarate dehydrogenase activity, acts as an oxidative phosphorylation uncoupler and metabolic inhibitor. 4-Methyl-2-oxopentanoic acid acts as a nutrient signal and stimulates skeletal muscle protein synthesis. 4-Methyl-2-oxopentanoic acid can be used in the study of maple syrup urine disease[1][2][3][4][5].
Molecular Weight:
130.14
Purity:
99.51
CAS Number:
[816-66-0]
Formula:
C6H10O3
Target:
Autophagy,Endogenous Metabolite,mTOR,SOD
Application Notes:
MCE Product type: Natural Products
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