Rizatriptan, CAS [[144034-80-0]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-W018475
Supplier Catalog Number:
HY-W018475
Alternative Catalog Number:
MCE-HY-W018475-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
Alternative Names:
MK 462 (free base)
Rizatriptan (MK 462 free base) is an orally active 5-HT1B/5-HT1D receptor agonist, with BBB permeability. Rizatriptan exerts significant anti-migraine effects by constricting intracranial and extracranial blood vessels and inhibiting neuropeptide release. Rizatriptan exhibits species- and tissue-specific metabolic characteristics, for example, it undergoes oxidative deamination mainly by MAO-A in the liver of brown rats, so co-administration with MAO-A inhibitors is prohibited. Rizatriptan may also exacerbate nitroglycerin-induced cutaneous allodynia, prolong the duration of central sensitization, and increase anxiety-like behavior and active drug-seeking behavior in mice. Rizatriptan has been widely used in studies related to migraine and medication-overuse headache[1][2].
Molecular Weight:
269.34
CAS Number:
[144034-80-0]
Formula:
C15H19N5
Target:
5-HT Receptor
Application Notes:
MCE Product type: Reference compound
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