Thalidomide 5-fluoride is a thalidomide-based Cereblon ligand used to recruit Cereblon protein. Thalidomide 5-fluoride can be linked to target protein ligands (e.g. IRAK4) through a linker to form PROTAC molecules (e.g. PROTAC IRAK4 degrader-1). PROTAC IRAK4 degrader-1 caused 20-50%, and >50% IRAK4 protein degradation in OCI-LY-10 cells at concentrations of 0.01, 0.1, and 1 µM, respectively[1][2].
Molecular Weight:
276.22
Purity:
99.96
CAS Number:
[835616-61-0]
Formula:
C13H9FN2O4
Target:
Apoptosis,Autophagy,Ligands for E3 Ligase
Application Notes:
MCE Product type: Reference compound
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