C1s-IN-1 trihydrochloride (Compound A1) is the selective inhibitor for C1s protease with the Ki of 5.8 µM. C1s-IN-1 trihydrochloride inhibits cleavage of C2 by C1s with an IC50 of 85 µM, inhibits the activation of classic pathway with an IC50 of 22 µM. C1s-IN-1 trihydrochloride is the competitive inhibitor for thrombin with the Ki of 51.2 µM[1].
Molecular Weight:
390.74
Purity:
99.73
CAS Number:
[1376162-36-5]
Formula:
C16H22Cl3N5
Target:
Complement System
Application Notes:
MCE Product type: Reference compound
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