CFL2 / NEM7 Antibody, IgG1, Clone: [CFL2/9963], Mouse, Monoclonal

Product Overview

• Article Name: CFL2 / NEM7 Antibody, IgG1, Clone: [CFL2/9963], Mouse, Monoclonal
• Biozol Catalog Number: NBT-1073-MSM3-P1ABX
• Supplier Catalog Number: 1073-MSM3-P1ABX
• Alternative Catalog Number: NBT-1073-MSM3-P1ABX-100
• Manufacturer: NeoBiotechnologies
• Host: Mouse
• Category: Antikörper
• Species Reactivity: Human
• Immunogen: Recombinant fragment (around aa1-166) of human CFL2 protein (exact sequence is proprietary)
• Alternative Names: NEM7

Product Description

Cofilin is ubiquitously expressed in eukaryotic cells where it binds to Actin, thereby regulating the rapid cycling of Actin assembly and disassembly essential for cellular viability. Cofilin is a low molecular weight protein that binds to filamentous (F) Actin by bridging two longitudinally associated Actin subunits changing the F-Actin filament twist. This process is allowed by the dephosphorylation of Cofilin Ser-3 by factors such as opsonized zymosan. Lim kinase 1, a serine kinase, phosphorylates Cofilin and renders it unable to bind and depolymerise F-Actin.

Product Properties

• Clonality: Monoclonal
• Clone Designation: [CFL2/9963]
• Molecular Weight: 19-21kDa
• Isotype: IgG1
• NCBI: 1073
• UniProt: Q9Y281
• Form: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.