Recombinant Topoisomerase II alpha (Proliferation & Drug-Resistance Marker) Antibody, Clone: [MSVA-802R], Rabbit, Monoclonal

Product Overview

• Article Name: Recombinant Topoisomerase II alpha (Proliferation & Drug-Resistance Marker) Antibody, Clone: [MSVA-802R], Rabbit, Monoclonal
• Biozol Catalog Number: NBT-7153-RBM12-P1
• Supplier Catalog Number: 7153-RBM12-P1
• Alternative Catalog Number: NBT-7153-RBM12-P1-100
• Manufacturer: NeoBiotechnologies
• Host: Rabbit
• Category: Antikörper
• Application: IHC
• Species Reactivity: Human
• Immunogen: Recombinant human Topoisomerase II alpha fragment (aa1352-1493) (exact sequence is proprietary)
• Alternative Names: ATP hydrolyzing DNA topoisomerase II alfa, DNA gyrase, DNA topoisomerase (ATP hydrolyzing), DNA topoisomerase 2 alpha, DNA topoisomerase II 170kD, DNA topoisomerase II alpha, Topoisomerase DNA II alpha 170kDa, TP2A

Product Description

The topoisomerase II-(TM) isoform is a 170kDa nuclear protein and plays an important role in DNA synthesis and RNA transcription, as well as chromosomal segregation during mitosis. Topoisomerase II-(TM) is reported to be a sensitive and specific marker of late S-, G2- & M-phases in transformed and developmentally regulated normal cells, and has been shown to be over-expressed in many human cancers. Decreased expression of Topoisomerase II-(TM) is the predominant mechanism of resistance to several chemotherapeutic agents.

Product Properties

• Clonality: Monoclonal
• Clone Designation: [MSVA-802R]
• Molecular Weight: 170kDa
• NCBI: 7153
• UniProt: P11388
• Form: Ab produced in HEK293 cell mammalian-based expression system. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide.

Images

DNA topoisomerase 2-alpha Rabbit Recombinant Monoclonal Antibody (MSVA-802R) tested on many normal and cancer tissues. The immunohistochemistry staining in these tissues aligns with the expression data in Human Protein Atlas.