DR1 Antibody (Down-regulator of transcription 1), Rabbit, Polyclonal
Biozol Catalog Number:
NSJ-F45943-0.4ML
Supplier Catalog Number:
F45943-0.4ML
Alternative Catalog Number:
NSJ-F45943-0.4ML
Manufacturer:
NSJ Bioreagents
Host:
Rabbit
Category:
Antikörper
Application:
ELISA, WB
Species Reactivity:
Human, Mouse
Immunogen:
A portion of amino acids 83-112 from the human protein was used as the immunogen for this DR1 antibody.
This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription.
