FGTI-2734 is a dual farnesyl transferase (FT) and geranylgeranyl transferase-1 (GGT-1) inhibitor, exhibiting IC50 values of 250 nM and 520 nM for FT and GGT-1, respectively. It effectively prevents the membrane localization of KRAS, addressing the issue of KRAS resistance and inhibiting the growth of mutant KRAS patient-derived pancreatic tumors.
Molecular Weight:
510.63
Purity:
99.36%
CAS Number:
[1247018-19-4]
Formula:
C26H31FN6O2S
Target:
Ras|||Transferase|||Kras
T11282
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