GNF4877 is a small molecule inhibitor, a potent dual-specificity kinase inhibitor targeting DYRK1A (IC50=6 nM) and GSK3beta (IC50=16 nM). This compound promotes beta-cell proliferation by blocking NFATc nuclear export (EC50=0.66 µM for mouse R7T1 cells) and is primarily used for research on beta-cell regeneration related to diabetes.
Molecular Weight:
494.52
Purity:
98.63%
CAS Number:
[2041073-22-5]
Formula:
C25H27FN6O4
Target:
GSK-3|||DYRK
T11447
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