MRTX-1257, CAS [[2206736-04-9]]

Product Overview

• Article Name: MRTX-1257, CAS [[2206736-04-9]]
• Biozol Catalog Number: TGM-T16143
• Supplier Catalog Number: T16143
• Alternative Catalog Number: TGM-T16143-1MLX10MM(INDMSO),TGM-T16143-1MG,TGM-T16143-2MG,TGM-T16143-5MG,TGM-T16143-10MG,TGM-T16143-25MG,TGM-T16143-50MG,TGM-T16143-100MG,TGM-T16143-200MG
• Manufacturer: TargetMol
• Category: Biochemikalien

Product Description

MRTX-1257 is a selective, irreversible, and covalent inhibitor of KRAS G12C with an IC50 of 900 pM for KRAS-dependent ERK phosphorylation in H358 cells. MRTX-1257 demonstrated 31% bioavailability in the mouse, with free fraction exposures well above cellular potency, and 77% target engagement in a PK/PD experiment.

Product Properties

• Molecular Weight: 565.71
• Purity: 96.59%
• CAS Number: [2206736-04-9]
• Formula: C33H39N7O2
• Target: Ras|||Kras

Images

T16143