Momelotinib (LM-1149) is an orally bioavailable small-molecule inhibitor of Janus kinases 1 and 2 (JAK1/2) with IC50 of 11 nM/18 nM. JAK1/2 inhibitor CYT387 competes with JAK1/2 for ATP binding, which may result in inhibition of JAK1/2 activation, inhibition of the JAK-STAT signaling pathway, and so the induction of apoptosis and a reduction of tumor cell proliferation in JAK1/2-expressing tumor cells.
Molecular Weight:
414.46
Purity:
97.07%
CAS Number:
[1056634-68-4]
Formula:
C23H22N6O2
Target:
Apoptosis|||JAK|||Autophagy
T1849
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