KAI-11101 is an inhibitor of dual leucine zipper kinase (DLK, MAP3K12) with a Ki of 0.7 nM. It effectively suppresses paclitaxel-induced cJun phosphorylation (IC50=95 nM), thereby inhibiting the activation of the MAPK pathway. KAI-11101 exhibits blood-brain barrier permeability, allowing for further exploration of its neuroprotective properties.
Molecular Weight:
469.433
CAS Number:
[3099935-02-8]
Formula:
C21H23F4N5O3
Target:
MAP3K|||p38 MAPK|||MAPK
T204384
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