ChREBPalpha/14-3-3 regulator-1 (Compound 43) is a selective molecular glue that stabilizes the interaction between carbohydrate response element-binding protein (ChREBP) and 14-3-3 proteins, with an EC50 of 3.8 µM. It effectively safeguards beta cells from glucolipotoxicity, preserving cell function and making it relevant for type 2 diabetes research.
Molecular Weight:
389.263
Formula:
C16H15F3NO5P
Target:
Molecular Glues
T204507
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