Semaxinib (SU5416) is a potent and selective VEGFR2 inhibitor (IC50: 1.23 µM), exhibiting a 20-fold greater selectivity for VEGFR2 over PDGFRbeta, with no activity against InsR, EGFR, and FGFR. Semaxinib reversibly inhibits ATP binding to the tyrosine kinase domain of VEGFR2, potentially inhibiting VEGF-stimulated endothelial cell migration and proliferation, thereby reducing tumor microvasculature.
Molecular Weight:
238.28
Purity:
99.15%
CAS Number:
[204005-46-9]
Formula:
C15H14N2O
Target:
VEGFR
T2064
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