HDAC3-IN-7 (Compound 8ae) is a selective HDAC3 inhibitor with an IC50 value of 311 nM. It effectively induces the degradation of PD-L1 via a cathepsin B-mediated lysosomal pathway, demonstrating the ability to inhibit tumor cell proliferation, migration, and invasion. HDAC3-IN-7 holds potential for cancer research.
Formula:
C25H37N5O4S
Target:
PD-1/PD-L1|||HDAC
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