PD-M6 is an mTOR PROTAC degrader with a DC50 of 4.8 µM, which facilitates the ubiquitination and degradation of mTOR. It inhibits the proliferation of cancer cell lines HeLa, MCF-7, and HepG2 with IC50 values of 11.3, 2.58, and 3.23 µM, respectively, and induces autophagy. Additionally, PD-M6 specifically targets the degradation of the key protein LAMTOR1 in the mTOR signaling pathway.
Molecular Weight:
621.69
CAS Number:
[3058330-82-5]
Formula:
C30H39N9O6
Target:
mTOR|||PROTACs
T207406
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