sEH-IN-21 is an orally active inhibitor of sEH, exhibiting IC50 values of 0.1 nM for both hsEH and msEH. It significantly suppresses the NF-kappaB signaling pathway. sEH-IN-21 demonstrates potent anti-inflammatory activity by reducing IL-6 and TNF-alpha release and maintaining intestinal barrier integrity. It is applicable in research on inflammatory bowel disease (IBD).
Molecular Weight:
568.73
CAS Number:
[3084814-46-7]
Formula:
C30H40N4O5S
Target:
TNF|||Epoxide Hydrolase|||Interleukin|||NF-kappaB
T211654
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