Conophyllidine, CAS [[152406-44-5]] Preis auf Anfrage
Biozol Catalog Number:
TGM-T211997
Supplier Catalog Number:
T211997
Alternative Catalog Number:
TGM-T211997-10MG,TGM-T211997-50MG
Manufacturer:
TargetMol
Category:
Biochemikalien
Conophyllidine is a bisindole alkaloid and functions as a selective inhibitor of M2 polarization. It inhibits histone acetylation by targeting the histone acetyltransferase domain of the P300/CBP proteins. The IC50 of Conophyllidine for IL-4-induced arginase inhibition is 0.31 µM. This compound effectively induces tumor-associated macrophages (TAMs) to shift from an anti-inflammatory to an inflammatory state, thereby enhancing the recruitment and function of cytotoxic CD8+ T cells in the tumor microenvironment. Conophyllidine is useful for studying tumor-associated macrophages.
Molecular Weight:
778.89
CAS Number:
[152406-44-5]
Formula:
C44H50N4O9
Target:
Histone Acetyltransferase|||Arginase
T211997
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