M6766 is a selective and potent inhibitor of endoplasmic reticulum oxidoreductase 1alpha (ERO1alpha), exhibiting an IC50 of 1.4 uM and a KD of 1.1 uM. It also inhibits ERO1beta with an IC50 of 7.2 uM. M6766 exerts its inhibitory effect by binding to the flavin adenine dinucleotide (FAD)-binding pocket of ERO1alpha. Functionally, M6766 suppresses granule secretion, alphaIIbbeta3 integrin activation, Ca2+ mobilization, and platelet aggregation. It serves as a significant chemical probe for investigating the molecular pathways of arterial thrombosis and neurological disorders, such as ischemic stroke.
Molecular Weight:
360.44
Purity:
99.17%
CAS Number:
[696628-90-7]
Formula:
C19H16N6S
Target:
Reactive Oxygen Species
T212821
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