MSU-44147 is a small-molecule inhibitor that targets the membrane transport protein MmpL3 in Mycobacterium abscessus. MSU-44147 exhibits selective anti-mycobacterial activity and low cytotoxicity toward eukaryotic cells. By inhibiting MmpL3-mediated lipid transport, MSU-44147 disrupts cell wall synthesis and biofilm formation, and exhibits bactericidal activity against intracellular bacteria, simultaneously, it produces additive or synergistic effects when used in combination with various antibiotics.
Molecular Weight:
313.36
Purity:
99.81%
CAS Number:
[3105177-29-2]
Formula:
C17H22F3NO
Target:
Antibacterial
T212840
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