Hakin-1 is an inhibitor of the E3 ubiquitin ligase Hakai. It effectively blocks both overall ubiquitination mediated by Hakai and the specific ubiquitination of E-cadherin, thereby inhibiting the process of epithelial-mesenchymal transition (EMT). Hakin-1 can impede tumor progression and cancer metastasis and is utilized for research in colorectal cancer and other cancers.
Molecular Weight:
385.35
CAS Number:
[346660-34-2]
Formula:
C16H11N5O5S
Target:
E1/E2/E3 Enzyme|||Cadherin
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