TC-N 22A is a strong, selective, oral active mGlu4 forward allosteric regulator (PAM) that can cross the blood-brain barrier. EC50 expression of TC-N 22A in BHK cells expressing human mGlu4 was 9 nM. TC-N 22A showed very low activity against mGlu 1, 2, 3, 5, and 7 receptors in excitation and forward allosteric models (EC50 >10 µM). TC-N 22A can be used in the study of central nervous system diseases.
Molecular Weight:
283.35
Purity:
99.95%
CAS Number:
[1314140-00-5]
Formula:
C14H13N5S
Target:
GluR
T23440
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