Plinabulin (NPI-2358) (NPI-2358) is a vascular disrupting agent (VDA) against tubulin-depolymerizing tumor cells ( IC50: 9.8-18 nM). Plinabulin selectively targets and binds to the colchicine-binding site of tubulin, thereby interrupting equilibrium of microtubule dynamics. This disrupts mitotic spindle assembly leading to cell cycle arrest at M phase and blockage of cell division.
Molecular Weight:
336.39
Purity:
91.68%
CAS Number:
[714272-27-2]
Formula:
C19H20N4O2
Target:
Microtubule Associated
T2511
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