BMS 182874 is an orally effective and highly selective endothelin receptor ETA antagonist with an IC50 value of 0.150 µM for ETA and a Ki value of 0.055 µM for ETA.BMS 182874 is able to reduce arterial pressure in a rat hypertension model induced by Deoxycorticosterone acetate. BMS 182874 was able to reduce Deoxycorticosterone-induced arterial pressure in a rat model of hypertension and can be used to study cardiovascular disease.
Molecular Weight:
345.42
Purity:
98.38%
CAS Number:
[153042-42-3]
Formula:
C17H19N3O3S
Target:
Endothelin Receptor
T26841
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