GDC0575 monohydrochloride (ARRY575) is a potent and selective inhibitor of cell cycle checkpoint kinase 1 (Chk1) with an IC50 of 1.2 nM. GDC-0575 specifically binds to and inhibits Chk1, this may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M phases, which permits the cells to undergo DNA repair prior to entry into mitosis.
Molecular Weight:
414.73
Purity:
0.9785
CAS Number:
[1196504-54-7]
Formula:
C16H21BrClN5O
Target:
Chk
T27407
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