COH29 (RNR Inhibitor COH29) is an orally available, aromatically substituted thiazole and human ribonucleotide reductase (RNR) inhibitor with potential antineoplastic activity. COH29 binds to the ligand-binding pocket of the RNR M2 subunit (hRRM2) near the C-terminal tail, decreasing the pool of deoxyribonucleotide triphosphates needed for DNA synthesis, leading to cell cycle arrest and growth inhibition. It may also inhibit the nuclear enzyme poly (ADP-ribose) polymerase (PARP) 1, preventing DNA repair, causing accumulation of DNA breaks, and inducing apoptosis.
Molecular Weight:
420.44
Purity:
98.92%
CAS Number:
[1190932-38-7]
Formula:
C22H16N2O5S
Target:
DNA/RNA Synthesis
T3157
* VAT and and shipping costs not included. Errors and price changes excepted
