AZD 1152 is an orally bioavailable prodrug of AZD 1152-HQPA, a selective inhibitor of Aurora kinase B (IC50= 0.36 nM).1AZD 1152 is converted to AZD 1152-HQPA in plasma. Inhibition of Aurora B results in disruption of spindle checkpoint functions and chromosome alignment, resulting in inhibition of cytokinesis followed by apoptosis.2,3AZD 1152 inhibits tumor xenograft growthin vivo.4,5
Molecular Weight:
660.47
CAS Number:
[722543-50-2]
Formula:
C26H33Cl2FN7O6P
Target:
Others|||Aurora Kinase|||Apoptosis
T36199
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