Nocardamine is a ferrioxamine siderophore that has been found inStreptomycesand has diverse biological activities.1,2,3,4It chelates iron in a chrome azurol S assay (IC50= 9.9 µM).1Nocardamine inhibitsM. smegmatisandM. bovisbiofilm formation (MIC = 10 µM for both), an effect that can be reversed by iron.2It is cytotoxic to T47D, SK-MEL-5, SK-MEL-28, and RPMI-7951 cancer cells (IC50s = 6, 18, 12, and 14 µM, respectively).3Nocardamine also induces morphological changes in BM-N4 insect cells.4
Molecular Weight:
600.7
CAS Number:
[26605-16-3]
Formula:
C27H48N6O9
Target:
Others
T36539
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