PROTAC IDO1 Degrader-1, a pioneering compound, efficiently targets indoleamine 2,3-dioxygenase 1 (IDO1) for ubiquitination and degradation by recruiting IDO1 to the CRBN E3 ligase, thereby facilitating its entry into the ubiquitin-proteasome system (UPS) with a DC50 of 2.84 µM. This compound also moderately enhances the tumor-killing efficacy of HER2 CAR-T cells[1].
Molecular Weight:
966.816
CAS Number:
[2488851-89-2]
Formula:
C40H53BrFN9O13
Target:
Indoleamine 2,3-Dioxygenase (IDO)|||IDO|||PROTACs
T37329
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