StA-IFN-1 is an inhibitor of the interferon (IFN) induction pathway with an IC50 value of 4.1 µM in a GFP reporter assay for IFN induction similar to TPCA-1 , which specifically inhibits the IKKbeta component of the IFN induction pathway. It does not show inhibitory activity in a GFP reporter assay for IFN signaling in which ruxolitinib , which is specific for the IFN signaling component JAK1, is active. StA-IFN-1 reduces the levels of IFN-beta, but not ISG MxA, mRNA, suggesting that it is selective for the IFN induction pathway and not the IFN signaling pathway.
Molecular Weight:
255.27
CAS Number:
[300839-31-0]
Formula:
C14H13N3O2
Target:
Others|||IFNAR
T38158
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