NSC 80467 is a selective DNA-damaging agent that functions through survivin inhibition. NSC 80467 preferentially disrupts DNA synthesis, thereby inducing two hallmark DNA-damage markers, gammaH2AX and pKAP1. NSC 80467 enables mechanistic investigation in to DNA replication stress and apoptosis-associated signaling pathways and serves as a biochemical tool for evaluating survivin-dependent cellular processes in oncology research.
Molecular Weight:
512.35
Purity:
99.25%
CAS Number:
[101982-51-8]
Formula:
C24H22BrN3O5
Target:
Survivin
T38414
T38414
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