PF-04577806 is a potent, selective, and ATP-competitive inhibitor of protein kinase C (PKC), showing significant inhibitory activity against various PKC isoforms, including PKCalpha (IC50=2.4 nM), PKCbetaI (IC50=8.1 nM), PKCbetaII (IC50=6.9 nM), PKCgamma (IC50=45.9 nM), and PKCtheta (IC50=29.5 nM). Additionally, it can reverse retinal vascular leakage in diabetic rats.
Molecular Weight:
495.628
CAS Number:
[1072100-81-2]
Formula:
C26H37N7O3
Target:
Others|||PKC|||Phosphatase
T38462
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