Vepdegestrant (ARV-471) is a selective and highly potent estrogen receptor (ER, ESR1) PROTAC degrader with strong degrading activity against the ER protein. By directly degrading the ER protein rather than merely antagonizing its activity, vepdegestrant effectively inhibits the ER signaling pathway and demonstrates significant antitumor activity in ER-positive (ER) breast cancer, with a DC50 value of approximately 2 nM. It is particularly effective against tumors harboring ESR1 mutations.
Molecular Weight:
723.9
Purity:
97.15%
CAS Number:
[2229711-68-4]
Formula:
C45H49N5O4
Target:
Estrogen Receptor/ERR|||PROTACs
T39710
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