AG126 (Tyrphostin AG126) selectively inhibits the phosphorylation of ERK1 (p44) and ERK2 (p42) at 25-50 µM. It blocks the production of TNF-alpha in vitro2 and in vivo, attenuating signaling through NF-kappaB, the induced expression of COX-2 and iNOS, and the inflammatory response in diverse animal models. AG-126 weakly inhibits epidermal GFRK (IC50: 450 µM) and platelet-derived GFRK (IC50 > 100 µM).
Molecular Weight:
215.16
Purity:
0.9872
CAS Number:
[118409-62-4]
Formula:
C10H5N3O3
Target:
ERK|||COX
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