Poseltinib is an orally active, selective, and irreversible inhibitor of Brutons tyrosine kinase (BTK), with an IC50 value of 1.95 nM. Poseltinib demonstrates 0.3-, 2.3-, and 2.4-fold higher selectivity for BTK over BMX, TEC, and TXK, respectively. Poseltinib covalently binds to cysteine 481 in BTKs active site, thereby inhibiting BCR-, FcR-, and TLR-mediated signaling pathways.
Molecular Weight:
470.52
Purity:
99.98%
CAS Number:
[1353552-97-2]
Formula:
C26H26N6O3
Target:
TLR|||BTK|||Others
T4413
T4413
* VAT and and shipping costs not included. Errors and price changes excepted
