A-674563 is an orally available, ATP-competitive, and reversible inhibitor of Akt (Ki: 11 nM for Akt1) [1]. It exhibits inhibitory activity against PKA and Cdk2 (IC50: 16/46 nM) but is 10- to >1, 800-fold selective for Akt1 versus additional kinases in the CMGC, CAMK, and TK families [1].
Molecular Weight:
394.9
Purity:
98%
CAS Number:
[2070009-66-2]
Formula:
C22H23ClN4O
Target:
ERK|||Akt|||CDK|||PKC|||PKA
T4444
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