Avapritinib (BLU-285) is a selective, highly potent, and orally active inhibitor of KIT and PDGFRA activation loop mutant kinases, targeting KIT D816V (IC50:0.27 nM) and PDGFRA D842V (IC50:0.24 nM), and attenuates the transport functions of ABCB1 and ABCG2. It binds to the active conformation of the kinases and exhibits antitumor activity.
Molecular Weight:
498.56
Purity:
99.70%
CAS Number:
[1703793-34-3]
Formula:
C26H27FN10
Target:
PDGFR|||c-Kit
T5109
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