Alofanib (RPT835) is a selective allosteric inhibitor of FGFR2 and has a dramatic inhibitory effect on FGF2-induced phosphorylation of FRS2a in KATO III cells (IC50 <10 nM). It has no direct effect on FGF2-dependent FGFR1 and FGFR3 phosphorylation levels in either cell lines and no effects on FGF2-FGFR2 binding.
Molecular Weight:
413.4
Purity:
99.81%
CAS Number:
[1612888-66-0]
Formula:
C19H15N3O6S
Target:
Apoptosis|||FGFR
T5122
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