CCT128930 hydrochloride (CCT128930 hydrochloride) is a potent and selective inhibitor of AKT with IC50 of 6 nM. CCT128930 hydrochloride induces cell cycle arrest, DNA damage, and autophagy. CCT128930 hydrochloride has 28-fold selectivity over the closely related PKA kinase (IC50: 168 nM) through the targeting of Met282 of AKT, as well as 20-fold selectivity over p70S6K (IC50: 120 nM).
Molecular Weight:
378.3
Purity:
98.55%
CAS Number:
[2453324-32-6]
Formula:
C18H21Cl2N5
Target:
Apoptosis|||Autophagy|||mTOR|||Akt|||PKA
T6303L
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