4-Me-PDTic is a potent and selective Kappa Opioid Receptor Antagonist. 4-Me-PDTic had a Ke = 0.37 nM in a [35S]GTPgammaS binding assay and was 645- and >8100-fold selective for the kappa relative to the µ and delta opioid receptors, respectively. Calculated logBB and CNS (central nervous system) multiparameter optimization (MPO) and low molecular weight values all predict that 4-Me-PDTic will penetrate the brain and pharmacokinetic studies in rats shows that 4-Me-PDTic does indeed penetrate the brain.
Molecular Weight:
432.43
CAS Number:
[2209073-52-7]
Formula:
C21H35Cl2N3O2
Target:
Others
T69798
* VAT and and shipping costs not included. Errors and price changes excepted
