Flavokawin B , Flavokavain B , 2-Hydroxy-4,6-Dimethoxychalcone
1. Flavokawain B (Flavokavain B) has potent anti-inflammatory activity, can significantly inhibit production of NO and PGE2 in LPS-induced RAW 264.7 cells. 2. Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-kappaB and MAPK signaling pathways. 3. Flavokawain B induces apoptosis, has the potential usefulness of FKB for prevention and treatment of hormone-refractory prostate cancer in an adjuvant setting. 4. Flavokawain B acts through ROS generation and GADD153 up-regulation to regulate the expression of Bcl-2 family members, thereby inducing mitochondrial dysfunction and apoptosis in HCT116 cells.
Molecular Weight:
284.31
Purity:
>99.99%
CAS Number:
[1775-97-9]
Formula:
C17H16O4
Target:
NF-kappaB|||PI3K|||ROS|||MMP|||Caspase|||Akt|||Apoptosis|||p38 MAPK|||PARP|||Bcl-2 Family
T6S0735
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