AM-8508 is a potent and selective PI3Kdelta inhibitor. AM-8508 showed good cellular potency (in vitro pAKT IC50 = 4.6 nM ). AM-8505 xhibited excellent HWB potency (HWB (pAKT) IC50 = 2.7 nM). AM-8508 inhibit KLH-specific antibodies in animal models, signifying its potential for the treatment of human inflammatory diseases. PI3Kalpha and PI3Kbeta are ubiquitously expressed and play a role in cell growth, division, and survival.
Molecular Weight:
374.37
CAS Number:
[1338483-67-2]
Formula:
C19H15FN8
Target:
Others
T70942
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