AT-1001 is an alpha3beta4 nAChR partial agonist. AT-1001 attenuates stress-induced reinstatement of nicotine seeking in a rat model of relapse and induces minimal withdrawal in dependent rats. AT-1001 also potently and reversibly blocks epibatidine-induced inward currents in HEK cells transfected with alpha3beta4 nAChR. Importantly, AT-1001 potently and dose-dependently blocks nicotine self-administration in rats, without affecting food responding. When tested in a nucleus accumbens (NAcs) synaptosomal preparation, AT-1001 inhibits nicotine-induced [H]dopamine release poorly and at significantly higher concentrations compared with mecamylamine and conotoxin MII.
Molecular Weight:
309.24
Purity:
98.26%
CAS Number:
[1314801-63-2]
Formula:
C15H21BrN2
Target:
AChR|||Others
T70987
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